The short answer
They operate at different layers of an agent system, so “which is best?” is usually the wrong question. A better one: which layer am I working at right now?
- MCP — connect one agent to tools, data and context.
- A2A — let independent agents delegate tasks to each other.
- Agent Protocol — give clients an API-style interface to an agent.
Side-by-side comparison
How they combine
In a realistic system you may use all three at once. A concrete pattern:
- A client calls your agent through an Agent Protocol REST endpoint (start a run, poll for steps).
- Inside, the agent uses MCP to read a database and call internal tools.
- For a specialised sub-task, it delegates to a peer agent over A2A and folds the result back in.
Choosing for your project
If you'd like a guided recommendation, the protocol selector asks five questions and suggests MCP, A2A, Agent Protocol, a custom API, or a hybrid. For depth on any single option, see the MCP, A2A and Agent Protocol guides.